To reduce the risk that hormone modulation with DHEA could contribute to a prostate problem, men taking DHEA are also advised to take:

We have previously recommended that men with severe benign prostate hypertrophy (BPH) avoid DHEA since DHEA may convert into estrogen and/or dihydrotestosterone (DHT), which could worsen the problem. Based on the newly identified benefits of DHEA, those with benign prostate disease may be able take low doses of DHEA if they also take an aromatase inhibitor such as the drug Arimidex (0.5 mg once or twice a week) only if estrogen levels are high and the drug Proscar (5 mg a day) to suppress excess DHT. A dietary supplement that functions as a mild aromatase inhibitor is the flavonoid chrysin (We compound Chrysin in 100mg capsules). Saw palmetto can block DHT activity on prostate cell receptor sites and nettle extract can block estrogen receptor sites on prostate cells.

Healthy men over 40 should consider checking their PSA and DHEA-s serum levels every 6 to 12 months. Men should also periodically check their blood levels for free testosterone and estrogen to make sure that DHEA is following a youthful metabolic pathway. We have available 7-keto-DHEA, a molecule which does not convert into Testosterone (applicable for the prostate patient)

Women

DHEA can increase serum estrogen levels in women and eliminate the need for estrogen replacement therapy in some women. To help protect cells (especially breast cells) from excessive proliferation in response to estrogen, women taking DHEA should also take additional supplements. (See box below.)

Women taking DHEA are also advised to take:

Women should consider estrogen and testosterone testing when they take their DHEA blood test in order to evaluate DHEA’s effect on their blood levels of estrogens.

Women who have been diagnosed with an estrogen-dependent cancer should consult their physicians before beginning DHEA therapy. Some studies indicate that higher serum DHEA protects against breast cancer, but no adequate studies have been done to evaluate the effects of DHEA in breast cancer patients. If DHEA were to elevate estrogen too much, this could theoretically increase the risk of breast cancer.

DHEA or 7-keto DHEA is available to be compounded in many dosage forms e.g. troche, cream, capsule, sublingual drop, topical lotion or suppository. Ask our compounding pharmacist for further information.